Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury

Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury

Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain. We investigated whether the increase of NKCC1 and KCC2 is associated with peripheral pain transmission in dorsal root ganglion neurons. To this aim...

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Bibliographic Details
Main Authors: Chao-Yang Tan, Yan-Ping Wang, Yuan-Yuan Han, Bi-Han Lu, Wei Ji, Li-Cang Zhu, Yang Wang, Wen-Yan Shi, Li-Ya Shan, Liang Zhang, Ke-Tao Ma, Li Li, Jun-Qiang Si
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
bumetanide; chronic constriction injury; dorsal root ganglion; dorsal root reflex; hyperalgesia; kcc2; nerve regeneration; neuropathic pain; nkcc1; primary afferent depolarization; whole-cell patch clamp
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=912;epage=921;aulast=Tan

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=912;epage=921;aulast=Tan

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