Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury.

Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury.

Ischemia-reperfusion (I/R) is a model of acute kidney injury (AKI) that is characterized by vasoconstriction, oxidative stress, apoptosis and inflammation. Previous studies have shown that activation of the renin-angiotensin system (RAS) may contribute to these processes. Angiotensin converting enzy...

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Bibliographic Details
Main Authors: Fei Fang, George Chu Liu, Xiaohua Zhou, Stuart Yang, Heather Naomi Reich, Vanessa Williams, Amanda Hu, Janice Pan, Ana Konvalinka, Gavin Yadram Oudit, James William Scholey, Rohan John
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3739768?pdf=render

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http://europepmc.org/articles/PMC3739768?pdf=render

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