Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.

Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.

Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is an RNA-binding protein that is normally localized in the nucleus, but is mislocalized to the cytoplasm in ALS, and compri...

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Main Authors: Hiroshi Sasayama, Mai Shimamura, Takahiko Tokuda, Yumiko Azuma, Tomokatsu Yoshida, Toshiki Mizuno, Masanori Nakagawa, Nobuhiro Fujikake, Yoshitaka Nagai, Masamitsu Yamaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3378546?pdf=render

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http://europepmc.org/articles/PMC3378546?pdf=render

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