Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.
Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is an RNA-binding protein that is normally localized in the nucleus, but is mislocalized to the cytoplasm in ALS, and compri...
Main Authors: | Hiroshi Sasayama, Mai Shimamura, Takahiko Tokuda, Yumiko Azuma, Tomokatsu Yoshida, Toshiki Mizuno, Masanori Nakagawa, Nobuhiro Fujikake, Yoshitaka Nagai, Masamitsu Yamaguchi |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3378546?pdf=render |
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