Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the di...

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Bibliographic Details
Main Authors: Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25514-6

Internet

https://doi.org/10.1038/s41467-021-25514-6

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