Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the di...

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Main Authors:	Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25514-6

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spelling	doaj-7935194eff76489e8d239c6329e3802f2021-09-05T11:44:14ZengNature Publishing GroupNature Communications2041-17232021-09-0112111310.1038/s41467-021-25514-6Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activationShubham Khetan0Susan Kales1Romy Kursawe2Alexandria Jillette3Jacob C. Ulirsch4Steven K. Reilly5Duygu Ucar6Ryan Tewhey7Michael L. Stitzel8The Jackson Laboratory for Genomic MedicineThe Jackson Laboratory for Mammalian GeneticsThe Jackson Laboratory for Genomic MedicineThe Jackson Laboratory for Genomic MedicineProgram in Biological and Biomedical Sciences, Harvard Medical SchoolBroad Institute of MIT and HarvardThe Jackson Laboratory for Genomic MedicineThe Jackson Laboratory for Mammalian GeneticsThe Jackson Laboratory for Genomic MedicineIdentifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.https://doi.org/10.1038/s41467-021-25514-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel
spellingShingle	Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation Nature Communications
author_facet	Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel
author_sort	Shubham Khetan
title	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_short	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_full	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_fullStr	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_full_unstemmed	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_sort	functional characterization of t2d-associated snp effects on baseline and er stress-responsive β cell transcriptional activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.
url	https://doi.org/10.1038/s41467-021-25514-6
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Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

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