Insulin Modulates Inflammatory Cytokine Release in Acute Stages and Augments Expression of Adhesion Molecules and Leukocytes in Lungs on Chronic Stages of Paracoccidioidomycosis

Insulin Modulates Inflammatory Cytokine Release in Acute Stages and Augments Expression of Adhesion Molecules and Leukocytes in Lungs on Chronic Stages of Paracoccidioidomycosis

Type 1 diabetesmellitus (T1D) is caused by partial destruction of the insulin-producing beta cells in the pancreas and is a major issue for public health care worldwide. Reduced or impaired immunological responses, which render patients more susceptible to infections, have been observed in T1D, and...

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Bibliographic Details
Main Authors: Felipe Beccaria Casagrande, Sabrina de Souza Ferreira, Emanuella Sarmento Alho de Sousa, João Pedro Tôrres Guimarães, Lavínia Maria Dal’Mas Romera, Fernando Henrique Galvão Tessaro, Sandro Rogério de Almeida, Stephen Fernandes de Paula Rodrigues, Joilson O. Martins
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
macrophages
type 1 diabetes
inflammation
Paracoccidioidomycosis
systemic mycosis
fungal infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583385/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.583385/full

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