Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models

BCL9 and Pygo are components of Wnt enhanceosome, which facilitates β-catenin-dependent transcription. Here, the authors show that deletion of Bcl9 and Pygo suppresses tumorigenesis and extends disease free survival in two different colorectal cancer models, suggesting a strategy for drugging β-cate...

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Bibliographic Details
Main Authors: Juliusz Mieszczanek, Laurens M. van Tienen, Ashraf E. K. Ibrahim, Douglas J. Winton, Mariann Bienz
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08164-z