Syntheses and Glycosidase Inhibitory Activities, and in Silico Docking Studies of Pericosine E Analogs Methoxy-Substituted at C6

Syntheses and Glycosidase Inhibitory Activities, and in Silico Docking Studies of Pericosine E Analogs Methoxy-Substituted at C6

Inspired by the significant -glucosidase inhibitory activities of (+)- and (−)-pericosine E, we herein designed and synthesized 16 analogs of these marine natural products bearing a methoxy group instead of a chlorine atom at C6. Four of these compounds exhibited moderate -glucosidase inhibitory a...

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Bibliographic Details
Main Authors: Yoshihide Usami, Megumi Higuchi, Koji Mizuki, Mizuki Yamamoto, Mao Kanki, Chika Nakasone, Yuya Sugimoto, Makio Shibano, Yoshihiro Uesawa, Junko Nagai, Hiroki Yoneyama, Shinya Harusawa
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Marine Drugs
Subjects:
pericosine E
marine natural product
C6-methoxy analogue
α-glucosidase inhibitor
anti-diabetes drug
docking simulation
Online Access:https://www.mdpi.com/1660-3397/18/4/221

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https://www.mdpi.com/1660-3397/18/4/221

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