Hypoxia-induced microRNA-141 regulates trophoblast apoptosis, invasion, and vascularization by blocking CXCL12β/CXCR2/4 signal transduction

Hypoxia-induced microRNA-141 regulates trophoblast apoptosis, invasion, and vascularization by blocking CXCL12β/CXCR2/4 signal transduction

Background: An impaired trophoblast invasion ability contributes to the development of pre-eclampsia (PE), and can be induced by the altered expression of various microRNAs (miRs). MiR-141 and CXCL12β (C-X-C motif chemokine ligand 12) signaling regulate trophoblast invasion and vascularization capab...

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Bibliographic Details
Main Authors: Dongcai Wu, Xiaoju Chen, Li Wang, Fangrong Chen, Hui Cen, Lei Shi
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Preeclampsia
Trophoblast
Apoptosis
Invasion
miR-141
CXCL12β
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218372512

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http://www.sciencedirect.com/science/article/pii/S0753332218372512

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