Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system

A heterozygous mutation in the TRK-Fused Gene (TFG1) has recently been identified in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). TFG1 protein is reportedly localized at endoplasmic reticulum (ER) exit sites and modulates ER export, but the mechanism of its ac...

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Bibliographic Details
Main Authors: Takuya Yagi, Daisuke Ito, Norihiro Suzuki
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Neurobiology of Disease
Subjects:
TRK-Fused Gene
Ubiquitin−Proteasome system
Amyotrophic lateral sclerosis
Neuropathy
Endoplasmic reticulum stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000539

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http://www.sciencedirect.com/science/article/pii/S0969996114000539

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