Plant HDAC inhibitor chrysin arrest cell growth and induce <it>p21</it><sup><it>WAF1</it></sup> by altering chromatin of STAT response element in A375 cells

Plant HDAC inhibitor chrysin arrest cell growth and induce <it>p21</it><sup><it>WAF1</it></sup> by altering chromatin of STAT response element in A375 cells

<p>Abstract</p> <p>Background</p> <p>Chrysin and its analogues, belongs to flavonoid family and possess potential anti-tumour activity. The aim of this study is to determine the molecular mechanism by which chrysin controls cell growth and induce apoptosis in A375 cells...

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Bibliographic Details
Main Authors: Pal-Bhadra Manika, Ramaiah M, Reddy T, Krishnan Anita, Pushpavalli SNCVL, Babu K, Tiwari Ashok K, Rao J, Yadav Jhillu S, Bhadra Utpal
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Cancer
Subjects:
HDAC-8
Chrysin
A375 cells
HDAC inhibitor
p21<sup>WAF1</sup>
Cell cycle arrest
p21 promoter
STAT
Apoptosis
Online Access:http://www.biomedcentral.com/1471-2407/12/180

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http://www.biomedcentral.com/1471-2407/12/180

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