Modulatory Influence of Segmented Filamentous Bacteria on Transcriptomic Response of Gnotobiotic Mice Exposed to TCDD

Modulatory Influence of Segmented Filamentous Bacteria on Transcriptomic Response of Gnotobiotic Mice Exposed to TCDD

Environmental toxicants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor (AhR), are known to induce host toxicity and structural shifts in the gut microbiota. Key bacterial populations with similar or opposing functional responses to AhR ligand exposure may potentiall...

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Bibliographic Details
Main Authors: Robert D. Stedtfeld, Benli Chai, Robert B. Crawford, Tiffany M. Stedtfeld, Maggie R. Williams, Shao Xiangwen, Tomomi Kuwahara, James R. Cole, Norbert E. Kaminski, James M. Tiedje, Syed A. Hashsham
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Microbiology
Subjects:
TCDD
segmented filamentous bacteria
gnotobiotic mice
regulatory T-cells
gut dysbiosis
host microbe response
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01708/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01708/full

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