Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

Abstract Background Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests that chronic neuroinflammation, mainly mediated by microglia and astro...

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Bibliographic Details
Main Authors: Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree, Xianlin Han
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Neurodegeneration
Subjects:
Sulfatide
Alzheimer’s disease
Astrogliosis
Microgliosis
Neuroinflammation
Cognitive impairment
Online Access:https://doi.org/10.1186/s13024-021-00488-7

Internet

https://doi.org/10.1186/s13024-021-00488-7

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