DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

Abstract Background DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and...

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Bibliographic Details
Main Authors: Ali Sharifi-Zarchi, Daniela Gerovska, Kenjiro Adachi, Mehdi Totonchi, Hamid Pezeshk, Ryan J. Taft, Hans R. Schöler, Hamidreza Chitsaz, Mehdi Sadeghi, Hossein Baharvand, Marcos J. Araúzo-Bravo
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Genomics
Subjects:
DNA methylation
Histone modifications
Promoters
Enhancers
H3K4me1
H3K4me3
Online Access:http://link.springer.com/article/10.1186/s12864-017-4353-7

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http://link.springer.com/article/10.1186/s12864-017-4353-7

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