Development of a target identification approach using native mass spectrometry

Abstract A key step in the development of new pharmaceutical drugs is the identification of the molecular target and distinguishing this from all other gene products that respond indirectly to the drug. Target identification remains a crucial process and a current bottleneck for advancing hits throu...

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Bibliographic Details
Main Authors: Miaomiao Liu, Wesley C. Van Voorhis, Ronald J. Quinn
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81859-4