CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain

CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain

Neuropathic pain is a chronic condition that remains a major clinical problem owing to high resistance to available therapy. Recent studies have indicated that chemokine signaling pathways are crucial in the development of painful neuropathy; however, the involvement of CC chemokine receptor 4 (CCR4...

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Bibliographic Details
Main Authors: Joanna Bogacka, Katarzyna Ciapała, Katarzyna Pawlik, Klaudia Kwiatkowski, Jan Dobrogowski, Anna Przeklasa-Muszynska, Joanna Mika
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
CCL17
CCL22
CCL2
chemokines
opioids
mice
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01241/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01241/full

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