Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

Several studies have implicated the enzyme acetylcholinesterase (AChE) as well as several biometals in the pathogenesis of Alzheimer's disease (AD). A multifunctional molecule, the hybrid tacrine-8-hydroxyquinoline (named IQM-622), displays cholinergic, antioxidant, copper-complexing and neurop...

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Bibliographic Details
Main Authors: Desiree Antequera, Marta Bolos, Carlos Spuch, Consuelo Pascual, Isidro Ferrer, María Isabel Fernandez-Bachiller, María Isabel Rodríguez-Franco, Eva Carro
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Acetylcholinesterase inhibitors
Aβ degradation
Domoic acid
Neuroprotection
Transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000800

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http://www.sciencedirect.com/science/article/pii/S0969996112000800

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