Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

Inflammation is the first step that leads to inflammatory cell migration, cytokine release, and myofibroblast formation. Myofibroblasts can deposit excess amounts of extracellular matrix. Cyclooxygenase (COX) inhibitor exhibits strong anti-inflammatory response; however, this is usually achieved wit...

Full description

Bibliographic Details
Main Authors: Chiming Lee, Jiahnhaur Liao, Seuhwa Chen, Chiaohan Yen, Yuchieh Lee, Shihhao Huang, Shengtung Huang, Chunmao Lin, Vincent Hungshu Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
inflammation
rutaecarpine
ROS
COX-2
KLF-10
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00091/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00091/full

Similar Items