Periostin Contributes to Cisplatin Resistance in Human Non-Small Cell Lung Cancer A549 Cells via Activation of Stat3 and Akt and Upregulation of Survivin

Periostin Contributes to Cisplatin Resistance in Human Non-Small Cell Lung Cancer A549 Cells via Activation of Stat3 and Akt and Upregulation of Survivin

Background/Aims: Periostin is upregulated in non-small cell lung cancer (NSCLC). This study was done to explore the function of periostin in the development of cisplatin (CDDP) resistance in NSCLC. Methods: The effects of overexpression or knockdown of periostin on CDDP sensitivity was examined in A...

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Bibliographic Details
Main Authors: Wenxia Hu, Pule Jin, Wei Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chemoresistance
Lung cancer
Periostin
Stat3 signaling
Therapeutic target
Online Access:http://www.karger.com/Article/FullText/443068

Internet

http://www.karger.com/Article/FullText/443068

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