Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

Abstract A key part of the optimization of small molecules in pharmaceutical inhibitor development is to vary the molecular design to enhance complementarity of chemical features of the compound with the positioning of amino acids in the active site of a target enzyme. Typically this involves iterat...

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Bibliographic Details
Main Authors: Joana Smirnovienė, Dr. Alexey Smirnov, Audrius Zakšauskas, Dr. Asta Zubrienė, Dr. Vytautas Petrauskas, Aurelija Mickevičiūtė, Vilma Michailovienė, Dr. Edita Čapkauskaitė, Dr. Elena Manakova, Prof. Saulius Gražulis, Dr. Lina Baranauskienė, Prof. Wen‐Yih Chen, Prof. John E. Ladbury, Prof. Daumantas Matulis
Format: Article
Language:English
Published: Wiley-VCH 2021-05-01
Series:ChemistryOpen
Subjects:
drug design
enzyme models
fluorescence spectroscopy
sulfonamides
X-ray diffraction
Online Access:https://doi.org/10.1002/open.202100042

Internet

https://doi.org/10.1002/open.202100042

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