Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH

Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH

In non-alcoholic steatohepatitis (NASH), decreased nitric oxide and increased endothelin-1 (ET-1, also known as EDN1) released by sinusoidal endothelial cells (LSEC) induce hepatic stellate cell (HSC) contraction and contribute to portal hypertension (PH). Statins improve LSEC function, and ambrisen...

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Bibliographic Details
Main Authors: Miren Bravo, Imma Raurell, Aurora Barberá, Diana Hide, Mar Gil, Federico Estrella, María Teresa Salcedo, Salvador Augustin, Joan Genescà, María Martell
Format: Article
Language:English
Published: The Company of Biologists 2021-05-01
Series:Disease Models & Mechanisms
Subjects:
ambrisentan
atorvastatin
endothelin-1
hepatic stellate cells
liver sinusoidal endothelial cells
nafld-nash
Online Access:http://dmm.biologists.org/content/14/5/dmm048884

Internet

http://dmm.biologists.org/content/14/5/dmm048884

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