Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca<sup>2+</sup> or Mg<sup>2+</sup>: Hints to Understand Protein Activity

Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca<sup>2+</sup> or Mg<sup>2+</sup>: Hints to Understand Protein Activity

The guanylyl cyclase-activating protein 1, GCAP1, activates or inhibits retinal guanylyl cyclase (retGC) depending on cellular Ca<sup>2+</sup> concentrations. Several point mutations of GCAP1 have been associated with impaired calcium sensitivity that eventually triggers progressive reti...

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Bibliographic Details
Main Authors: Francesco Bonì, Valerio Marino, Carlo Bidoia, Eloise Mastrangelo, Alberto Barbiroli, Daniele Dell’Orco, Mario Milani
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomolecules
Subjects:
quaternary assembly
calcium-binding proteins
EF-hand
protein-protein interaction
small-angle X-ray scattering
molecular dynamics simulations
Online Access:https://www.mdpi.com/2218-273X/10/10/1408

Internet

https://www.mdpi.com/2218-273X/10/10/1408

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