MicroRNA-221 Modulates Airway Remodeling via the PI3K/AKT Pathway in OVA-Induced Chronic Murine Asthma

MicroRNA-221 Modulates Airway Remodeling via the PI3K/AKT Pathway in OVA-Induced Chronic Murine Asthma

BackgroundAirway remodeling is one of the most important pathological features of chronic asthma. This study aimed to determine whether microRNA-221 (hereafter, miR-221) can affect airway remodeling in a mouse model of ovalbumin (OVA)-induced chronic asthma.MethodsAdeno-associated viruses (AAVs) “Be...

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Bibliographic Details
Main Authors: Jing Pan, Qianyuan Yang, Yao Zhou, Huan Deng, Yifan Zhu, Deyu Zhao, Feng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
miR-221
asthma
airway inflammation
airway remodeling
ASMCs
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00495/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00495/full

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