Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors

Design, synthesis, and biological evaluation of symmetrical azine derivatives as novel tyrosinase inhibitors

Abstract A series of symmetrical azine derivatives containing different substituted benzyl moieties were designed, synthesized, and evaluated for their inhibitory activity against tyrosinase. The results showed that compounds 3e, 3f, 3h, 3i, 3j, and 3k possess effective tyrosinase inhibition with IC...

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Bibliographic Details
Main Authors: Somaye Karimian, Fatemeh Kazemi, Mahshid Attarroshan, Maryam Gholampour, Shiva Hemmati, Amirhossein Sakhteman, Yasaman Behzadipour, Maryam Kabiri, Aida Iraji, Mehdi Khoshneviszadeh
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Chemistry
Subjects:
Melanin
Azine derivatives
Tyrosinase inhibitors
Molecular docking
Online Access:https://doi.org/10.1186/s13065-021-00780-z

Internet

https://doi.org/10.1186/s13065-021-00780-z

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