Systematic genetics and single‐cell imaging reveal widespread morphological pleiotropy and cell‐to‐cell variability

Systematic genetics and single‐cell imaging reveal widespread morphological pleiotropy and cell‐to‐cell variability

Abstract Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to‐cell phenotypic variability, we combined automated yeast genetics, high‐content screening and neural netw...

Full description

Bibliographic Details
Main Authors: Mojca Mattiazzi Usaj, Nil Sahin, Helena Friesen, Carles Pons, Matej Usaj, Myra Paz D Masinas, Ermira Shuteriqi, Aleksei Shkurin, Patrick Aloy, Quaid Morris, Charles Boone, Brenda J Andrews
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Systems Biology
Subjects:
cell‐to‐cell variability
endocytosis
high‐content screening
phenotype classification
single‐cell analysis
Online Access:https://doi.org/10.15252/msb.20199243

Internet

https://doi.org/10.15252/msb.20199243

Similar Items