Integrative Analysis of Genome and Expression Profile Data Reveals the Genetic Mechanism of the Diabetic Pathogenesis in Goto Kakizaki (GK) Rats

Integrative Analysis of Genome and Expression Profile Data Reveals the Genetic Mechanism of the Diabetic Pathogenesis in Goto Kakizaki (GK) Rats

The Goto Kakizaki (GK) rats which can spontaneously develop type 2 diabetes (T2D), are generated by repeated inbreeding of Wistar rats with glucose intolerance. The glucose intolerance in GK rat is mainly attributed to the impairment in glucose-stimulated insulin secretion (GSIS). In addition, GK ra...

Full description

Bibliographic Details
Main Authors: Yuhuan Meng, Ying Cui, Wenlu Zhang, Shuying Fu, Lizhen Huang, Hua Dong, Hongli Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
diabetes
GK rat
genome
population genetic
putative artificial selective sweeps
glucose-stimulated insulin secretion
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00724/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00724/full

Similar Items