Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin changes underlying astrocyte maturation in mice and...

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Bibliographic Details
Main Authors: Michael Lattke, Robert Goldstone, James K. Ellis, Stefan Boeing, Jerónimo Jurado-Arjona, Nicolás Marichal, James I. MacRae, Benedikt Berninger, Francois Guillemot
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24624-5