Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease

Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease

Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). A number of studies support a role for B cells in the pathogenesis of cGvHD. In this study, we report the presence of an expanded population of CD19+CD21− B cells with...

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Bibliographic Details
Main Authors: Ahmad Khoder, Abdullah Alsuliman, Rafet Basar, Catherine Sobieski, Kayo Kondo, Amin Majid Alousi, Richard Szydlo, Muharrem Muftuoglu, Hila Shaim, Jane F. Apperley, Elif Gokdemir, Nichola Cooper, Rohtesh S. Mehta, David Marin, Richard Champlin, Elizabeth Shpall, Katayoun Rezvani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
chronic graft-versus-host disease
CD19+CD21−CD27−CD10− cells
exhausted B cells
stem cell transplantation
CD21– B cells correlate with cGVHD severity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01937/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01937/full

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