From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity

From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity

Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophy...

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Bibliographic Details
Main Authors: Koen T. Scholman, Veronique M. F. Meijborg, Carolina Gálvez-Montón, Elisabeth M. Lodder, Bastiaan J. Boukens
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
GWAS
cardiac electrophysiology
arrhythmias
gene expression
genetics
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00557/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00557/full

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