Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ

Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations in the gene encoding for IGHMBP2, an ATPase/Helicase. Paralysis of the diaphragm is an early and prominent clinical sign resulting both from denervation and myopathy. In skeletal m...

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Bibliographic Details
Main Authors: Frank Krieger, Nicole Elflein, Rocio Ruiz, Joana Guerra, Antonio L. Serrano, Esther Asan, Lucia Tabares, Sibylle Jablonka
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
SMARD1
Nmd2J mouse
Motor axon
Neuromuscular junction
Neurotransmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112004020

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http://www.sciencedirect.com/science/article/pii/S0969996112004020

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