Fasudil reduces β-amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice via inhibition of the Nogo-A/NgR/RhoA signaling axis

Fasudil reduces β-amyloid levels and neuronal apoptosis in APP/PS1 transgenic mice via inhibition of the Nogo-A/NgR/RhoA signaling axis

Recent studies have shown that Nogo-A and the Nogo-A receptor affect β-amyloid metabolism and the downstream Rho GTP enzyme signaling pathway, which may affect the levels of β-amyloid and tau. Nogo-A may play a key role in the pathogenesis of Alzheimer's disease. However, the underlying molecul...

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Bibliographic Details
Main Authors: Min-Fang Guo, Hui-Yu Zhang, Pei-Jun Zhang, Xiao-Qin Liu, Li-Juan Song, Wen-Yue Wei, Yu-Yin Wang, Bing-Tao Mu, Zhi Chai, Jie-Zhong Yu, Cun-Gen Ma
Format: Article
Language:English
Published: IMR (Innovative Medical Research) Press Limited 2020-12-01
Series:Journal of Integrative Neuroscience
Subjects:
fasudil
alzheimer's disease
β-amyloid
apoptosis
nogo-a/ngr/rhoa
hyper-phosphorylated tau (p-tau)
Online Access:https://jin.imrpress.com/fileup/1757-448X/PDF/1609231250911-842876839.pdf

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https://jin.imrpress.com/fileup/1757-448X/PDF/1609231250911-842876839.pdf

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