Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

Objective: Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in humans. However, the function of seipin in adipogenesis remains poorly defined. We demonstrated recently that seipin can bi...

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Bibliographic Details
Main Authors: Md. Mesbah Uddin Talukder, M.F. Michelle Sim, Stephen O'Rahilly, J. Michael Edwardson, Justin J. Rochford
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Molecular Metabolism
Subjects:
Lipodystrophy
BSCL2
AGPAT2
Lipin
Seipin
Lipid synthesis
Adipocyte
Adipogenesis
Atomic force microscopy (AFM)
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877814002269

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http://www.sciencedirect.com/science/article/pii/S2212877814002269

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