Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus

Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus

Abstract Background Sexual differentiation of the male brain, and specifically the stress circuitry in the hypothalamus, is primarily driven by estrogen exposure during the perinatal period. Surprisingly, this single hormone promotes diverse programs of sex-specific development that vary widely betw...

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Bibliographic Details
Main Authors: Christopher P. Morgan, Tracy L. Bale
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Biology of Sex Differences
Subjects:
microRNA
Argonaute HITS-CLIP
Sexual differentiation
miRNA-target gene networks
Epigenetic programming
Hypothalamus
Online Access:http://link.springer.com/article/10.1186/s13293-017-0149-3

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http://link.springer.com/article/10.1186/s13293-017-0149-3

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