The role of HPV16 regulatory region methylation in viral oncogenes E6 and E7 eхpression in primary cervical cancer lesions

The role of HPV16 regulatory region methylation in viral oncogenes E6 and E7 eхpression in primary cervical cancer lesions

Background. Overexpression of the human papillomavirus oncogenes E6 and E7 is a major factor in initiation and progression of HPV-induced tumors. Inactivation of negative regulatory function of E2 protein – the main viral transcription and replication regulator – is considered to be an important mec...

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Bibliographic Details
Main Authors: P. M. Abramov, A. N. Katargin, M. D. Fedorova, N. P. Kisseljova, L. S. Pavlova, S. V. Vinokurova
Format: Article
Language:Russian
Published: ABV-press 2019-01-01
Series:Uspehi Molekulârnoj Onkologii
Subjects:
human papillomavirus
cervical cancer
methylation
regulation of expression
viral oncogene e6
viral oncogenes e7
Online Access:https://umo.abvpress.ru/jour/article/view/180

Internet

https://umo.abvpress.ru/jour/article/view/180

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