Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.

Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated inflammatory diseases such as Castleman's Disease (CD) and rheumatoid arthritis (RA). Antagonism of the...

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Main Authors: Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang, Christopher Leitheiser, Sylvie G Bernier, Guang Liu, Tran T Tran, Herodion Celino, Jenny Tobin, Joon Jung, Hong Zhao, Katie E Glen, Chris Graul, Aliesha Griffin, Wayne C Schairer, Carolyn Higgins, Tammi L Reza, Eva Mowe, Sam Rivers, Sonya Scott, Alex Monreal, Courtney Shea, Greg Bourne, Casey Coons, Adaline Smith, Kim Tang, Ramya A Mandyam, Jaime Masferrer, David Liu, Dinesh V Patel, Angelika Fretzen, Craig A Murphy, G Todd Milne, Mark L Smythe, Kenneth E Carlson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4640888?pdf=render

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http://europepmc.org/articles/PMC4640888?pdf=render

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