An improved preparation of phorbol from croton oil

Background: Croton oil is the only commercial source of the diterpenoid phorbol (1a), the starting material for the semi-synthesis of various diesters extensively used in biomedical research to investigate cell function and to evaluate in vivo anti-inflammatory activity. While efficient chemoselecti...

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Bibliographic Details
Main Authors: Alberto Pagani, Simone Gaeta, Andrei I. Savchenko, Craig M. Williams, Giovanni Appendino
Format: Article
Language:English
Published: Beilstein-Institut 2017-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.13.133