Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.

Bibliographic Details
Main Authors: Michael Tyler, Itay Tirosh
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22800-1