B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making

B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making

The clonotypic B cell receptor immunoglobulin (BcR IG) plays a seminal role in B cell lymphoma development and evolution. From a clinical perspective, this view is supported by the remarkable therapeutic efficacy of BcR signaling inhibitors, even among heavily pre-treated, relapsed/refractory patien...

Full description

Bibliographic Details
Main Authors: Katerina Gemenetzi, Andreas Agathangelidis, Laura Zaragoza-Infante, Electra Sofou, Maria Papaioannou, Anastasia Chatzidimitriou, Kostas Stamatopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia (CLL)
mantle cell lymphoma (MCL)
germinal center (GC)
immunogenetics
ontogeny
patient prognosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00067/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00067/full

Similar Items