Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii,...

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Bibliographic Details
Main Authors: Irini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen, Sileshi Gizachew Wubshet, Allison Maree Heskes, Victor Forman, Björn Hallström, Britta Hamberger, Mohammed Saddik Motawia, Carl Erik Olsen, Dan Staerk, Jørgen Hansen, Birger Lindberg Møller, Björn Hamberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
Coleus forskohlii
forskolin
diterpenoids biosynthesis
pathway elucidation
Online Access:https://elifesciences.org/articles/23001

Internet

https://elifesciences.org/articles/23001

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