Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles

Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles

Glucocorticoids are frequently used as anti-inflammatory and immunosuppressive agents. However, high doses and/or prolonged use induce undesired secondary effects such as muscular atrophy. Recently, de novo expression of connexin43 and connexin45 hemichannels (Cx43 HCs and Cx45 HCs, respectively) ha...

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Bibliographic Details
Main Authors: Elisa Balboa, Fujiko Saavedra, Luis A. Cea, Valeria Ramírez, Rosalba Escamilla, Aníbal A. Vargas, Tomás Regueira, Juan C. Sáez
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
connexons
mitochondrial dysfunction
oxidative stress
muscle atrophy
dexamethasone
Online Access:https://www.mdpi.com/1422-0067/21/11/4094

Internet

https://www.mdpi.com/1422-0067/21/11/4094

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