Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases

Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases

Worldwide dissemination of pathogens resistant to almost all available antibiotics represent a real problem preventing efficient treatment of infectious diseases. Among antimicrobial used in therapy, β-lactam antibiotics represent 40% thus playing a crucial role in the management of infecti...

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Bibliographic Details
Main Authors: Pasquale Linciano, Mattia Vicario, Ivana Kekez, Pierangelo Bellio, Giuseppe Celenza, Isabel Martín-Blecua, Jesús Blázquez, Laura Cendron, Donatella Tondi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antibiotics
Subjects:
serine β-lactamases
carbapenemases
kpc-2 klebsiella pneumoniae
ges-5 guyana extended-spectrum-lactamase
boronic acid
enzyme inhibitors
x-ray crystallography
synergism
Online Access:https://www.mdpi.com/2079-6382/8/4/171

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https://www.mdpi.com/2079-6382/8/4/171

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