Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.

Bibliographic Details
Main Authors: Li-Qiu Wang, Tao Liu, Shuai Yang, Lin Sun, Zhi-Yao Zhao, Li-Yue Li, Yuan-Chu She, Yan-Yan Zheng, Xiao-Yan Ye, Qing Bao, Guang-Hui Dong, Chun-Wei Li, Jun Cui
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23201-0

Internet

https://doi.org/10.1038/s41467-021-23201-0

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