Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.
Bibliographic Details
Main Authors: |
Li-Qiu Wang,
Tao Liu,
Shuai Yang,
Lin Sun,
Zhi-Yao Zhao,
Li-Yue Li,
Yuan-Chu She,
Yan-Yan Zheng,
Xiao-Yan Ye,
Qing Bao,
Guang-Hui Dong,
Chun-Wei Li,
Jun Cui |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-021-23201-0
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