Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.
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2021-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-23201-0 |
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doaj-79bf5e4585bd4a3daeb1b694c9b9e1b52021-05-23T11:13:18ZengNature Publishing GroupNature Communications2041-17232021-05-0112111710.1038/s41467-021-23201-0Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasomeLi-Qiu Wang0Tao Liu1Shuai Yang2Lin Sun3Zhi-Yao Zhao4Li-Yue Li5Yuan-Chu She6Yan-Yan Zheng7Xiao-Yan Ye8Qing Bao9Guang-Hui Dong10Chun-Wei Li11Jun Cui12MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityThe double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.https://doi.org/10.1038/s41467-021-23201-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui |
spellingShingle |
Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome Nature Communications |
author_facet |
Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui |
author_sort |
Li-Qiu Wang |
title |
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome |
title_short |
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome |
title_full |
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome |
title_fullStr |
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome |
title_full_unstemmed |
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome |
title_sort |
perfluoroalkyl substance pollutants activate the innate immune system through the aim2 inflammasome |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-05-01 |
description |
The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells. |
url |
https://doi.org/10.1038/s41467-021-23201-0 |
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