Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.

Bibliographic Details
Main Authors:	Li-Qiu Wang, Tao Liu, Shuai Yang, Lin Sun, Zhi-Yao Zhao, Li-Yue Li, Yuan-Chu She, Yan-Yan Zheng, Xiao-Yan Ye, Qing Bao, Guang-Hui Dong, Chun-Wei Li, Jun Cui
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23201-0

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spelling	doaj-79bf5e4585bd4a3daeb1b694c9b9e1b52021-05-23T11:13:18ZengNature Publishing GroupNature Communications2041-17232021-05-0112111710.1038/s41467-021-23201-0Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasomeLi-Qiu Wang0Tao Liu1Shuai Yang2Lin Sun3Zhi-Yao Zhao4Li-Yue Li5Yuan-Chu She6Yan-Yan Zheng7Xiao-Yan Ye8Qing Bao9Guang-Hui Dong10Chun-Wei Li11Jun Cui12MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen UniversityDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen UniversityMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityThe double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.https://doi.org/10.1038/s41467-021-23201-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui
spellingShingle	Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome Nature Communications
author_facet	Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui
author_sort	Li-Qiu Wang
title	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_short	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_full	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_fullStr	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_full_unstemmed	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_sort	perfluoroalkyl substance pollutants activate the innate immune system through the aim2 inflammasome
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.
url	https://doi.org/10.1038/s41467-021-23201-0
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Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

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