PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling

PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling

Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions between patient-derived MDSCs and circulating tumors cells (CTCs) within the microenvironment of blood remain un...

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Bibliographic Details
Main Authors: Marc L. Sprouse, Thomas Welte, Debasish Boral, Haowen N. Liu, Wei Yin, Monika Vishnoi, Debalina Goswami-Sewell, Lili Li, Guangsheng Pei, Peilin Jia, Isabella C. Glitza-Oliva, Dario Marchetti
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
circulating tumor cells (CTCs)
polymorphonuclear-myeloid derived suppressor cells (PMN-MDSCs)
Heterotypic CTC clusters
mutual CTC/PMN-MDSC activation cycle
biomarkers and signaling pathways
breast cancer
melanoma
Online Access:https://www.mdpi.com/1422-0067/20/8/1916

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https://www.mdpi.com/1422-0067/20/8/1916

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