Loss of function Cbl-c mutations in solid tumors.

Loss of function Cbl-c mutations in solid tumors.

Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are a family of RING finger (RF) ubiquitin ligases that negatively regulate a variety of RTKs, inc...

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Bibliographic Details
Main Authors: Silvano Rakeem Daniels, Mariya Liyasova, Stephen C Kales, Marion M Nau, Philip E Ryan, Jeffrey E Green, Stanley Lipkowitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0219143

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https://doi.org/10.1371/journal.pone.0219143

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