Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity

Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity

Abstract Mutations in the Presenilin genes are the major genetic cause of Alzheimer's disease (AD). Presenilin (PS) is highly expressed in the hippocampus, which is particularly vulnerable in AD. Previous studies of PS function in the hippocampus, however, focused exclusively on excitatory neur...

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Bibliographic Details
Main Authors: Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Brain
Subjects:
Alzheimer’s disease
Interneuron
Conditional knockout
Hippocampus
Schaffer collateral
Short-term synaptic plasticity
Online Access:https://doi.org/10.1186/s13041-021-00796-5

Internet

https://doi.org/10.1186/s13041-021-00796-5

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