FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.

FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.

The FERM domain containing protein 7 gene (FRMD7) associated with the X-linked disorder idiopathic congenital nystagmus (ICN) is involved in the regulation of neurite elongation during neuronal development. Members of the Rho family of small G-proteins (Rho GTPases) are key regulators of the actin c...

Full description

Bibliographic Details
Main Authors: Jiali Pu, Yanfang Mao, Xiaoguang Lei, Yaping Yan, Xiaoxiong Lu, Jun Tian, Xinzhen Yin, Guohua Zhao, Baorong Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742540?pdf=render

Internet

http://europepmc.org/articles/PMC3742540?pdf=render

Similar Items