The Long Linker Region of Telomere-Binding Protein TRF2 Is Responsible for Interactions with Lamins

The Long Linker Region of Telomere-Binding Protein TRF2 Is Responsible for Interactions with Lamins

Telomere-binding factor 2 (TRF2) is part of the shelterin protein complex found at chromosome ends. Lamin A/C interacts with TRF2 and influences telomere position. TRF2 has an intrinsically disordered region between the ordered dimerization and DNA-binding domains. This domain is referred to as the...

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Bibliographic Details
Main Authors: Aleksandra O. Travina, Nadya V. Ilicheva, Alexey G. Mittenberg, Sergey V. Shabelnikov, Anastasia V. Kotova, Olga I. Podgornaya
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
telomere
TRF2
chromosome organization
lamins
nuclear lamina
Online Access:https://www.mdpi.com/1422-0067/22/7/3293

Internet

https://www.mdpi.com/1422-0067/22/7/3293

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